Tatiana Schlossberg, granddaughter of President John F. Kennedy, has brought national attention to acute myeloid leukemia (AML) through her deeply personal essay in The New Yorker. Diagnosed shortly after giving birth to her second child in May 2024, Schlossberg revealed she is battling a rare and aggressive subtype of AML called “inversion 3, which carries an inferior prognosis. Her story has sparked widespread awareness about the sudden and devastating nature of this cancer, especially in young, otherwise healthy individuals.
Schlossberg’s specific subtype is exceptionally rare, found in only 1% to 2% of AML cases. This genetic abnormality involves a chromosomal inversion that disrupts the normal function of genes like EVI1 and GATA2, leading to uncontrolled cell growth and resistance to standard therapies. Patients with AML typically have an inferior prognosis, with remission rates after initial treatment as low as 31–46% and long-term survival rates below 5–9% at three years.
The cancer is highly aggressive, often relapsing quickly and responding poorly to chemotherapy. Allogeneic stem cell transplantation offers the best chance for remission, but even then, outcomes remain dismal.
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